Giant-Size Spider-Man#5(1975)

While web-slinging through the city, Spider-Man realizes that he needs to get away from New York, and sort out the state of his life. He happens to see a news reports concerning the Man-Thing's activities in Florida, and decides to try and convince J. Jonah Jameson to send Peter Parker out to Florida to try and get pictures of the monster. After convincing Jameson, Peter calls his old friend Dr. Curt Connors, who agrees to to help him out, since he lives in Florida. Next, Peter calls Mary Jane, who is excited that he's called her, but disappointed when he tells her he's leaving town for a few days. She quickly hides this disappointment when her Aunt Anna enters the room. Meanwhile in Florida, Curt Connors accidentally knocks over a beaker containing a chemical mixture, the gas from which causes him to once more turn into the Lizard. He attacks Connors' wife, Martha, before returning to the swamps. Once there, the Lizard rants about making lizards the dominant life form on the planet. Upon seeing the Man-Thing, he realizes the creature poses a threat to his plans. Before leaving New York for Florida, Peter pays a visit to Gwen Stacy, and apologizes for his behavior following her sudden "resurrection." Meanwhile in Florida, Edmond Arnstead, a down-and-out biochemist who has become bankrupt due to the recent recession, has come to the swamps in order to commit suicide. Before he can do that, he is saved by the Man-Thing, the bog-beast being attracted to his emotions and the arrival of a huge alligator. Realizing that he's discovered the location of the Man-Thing, Arnstead realizes the money making potential and leaves the scene via his car. Elsewhere, Spider-Man has finally reached Florida, but before he can arrive at the Connors home, he's suddenly attacked by the Lizard. However, with Martha Connors' help, Spider-Man is able to gain the upper hand against the creature and bind him with his webbing. With the Lizard incapacitated, they debate on how best to deal with him. Elsewhere in the swamp, Edmond has been tracking the Man-Thing, figuring that if he can somehow capture it, he can make money off the creature. He follows the bog-beast, as it and various lizards are drawn to the Lizard's mental commands for aid. When the various reptiles and the Man-Thing arrive on the Connors property, Spider-Man mistakenly attacks the Man-Thing, while the lizards free the Lizard. When Spider-Man realizes what's really going on, he attacks the Lizard, with an assist from the Man-Thing. Meanwhile, after Edmond is informed that Connors and the Lizard are one and the same, he has the doctor's wife take him to the lab, where Edmond uses his scientific knowledge to come up with a cure. Upon arriving in the middle of the battle, Edmond almost drops the cure, but Spider-Man saves it from a spill with his webbing and proceeds to use it on the Lizard, who transforms back into Curt Connors. With the mental control gone, the various lizards and the Man-Thing return to the swamp. Edmond tells all present that until he met the Man-Thing he figured his life was over, but now has given things a second thought and is going to give life a second chance.