Deadpool Kills the Marvel Universe Again #1 (2017)

The story begins with a squad of police officers standing in front of a bar in New Orleans, while a group of unknown characters stand at the doorway looking in, where Gambit has been killed. They theorize who did it, and one character comments that whoever did the killing thoroughly enjoyed it. Action currently happening on A.I.M. Island is then shown, where Deadpool is displayed fighting A.I.M. Agents alongside his teammates of the Avengers Unity Division. Deadpool advances to kill the enemies' leader, M.O.D.O.K., but before he dies M.O.D.O.K. speaks a few code words that trigger programming in Deadpool's brain, causing him to see all of his teammates as bright, fun-colored enemies. Deadpool proceeds to kill all of his teammates, not realizing who they are. Later, a group of heroes including Jessica Jones, Hawkeye, Mr. Knight, Cable, Misty Knight, and Punisher are looking over the massacre on A.I.M. Island, and find Deadpool's symbol drawn in blood on the floor. Deadpool, meanwhile, is still in a trance and is seeing everything as happy and bright versions of the world even though in reality he is sitting in a dingy, abandoned room in Schaefer Theater. He receives a call on the telephone from a mysterious caller who uses the code words again to give Deadpool more instructions, but in Deadpool's trance-induced vision he sees it as Nick Fury calling for him with a special heroic assignment. The scene fast-forwards to Loki, Valkyrie, Hercules, Thor, Hippolyta, and Ganesha all appearing on an island in the Aegean Sea after being summoned there by cries of help from other gods. There they find a plethora of gods all turned to stone and Deadpool standing above them all, thinking that they are his friends all having a beach party together. Deadpool holds up what he thinks is a volleyball, but is actually Medusa's head, and turns all of the new arrivals to stone as well. During this, the group of heroes that were investigating at A.I.M. Island bust into Deadpool's room in Schaffer Theater. There they find detailed files containing weaknesses and strategies for killing all of the deceased heroes they have seen so far, confirming to them that Deadpool is the killer. They see that he received a phone call from someone before leaving, but they also find a message from Deadpool reading "Help Me" written on a desk pizza cheese. Finally, an ominous scene reveals the Red Skull, Abomination, Magneto, and Doctor Doom are the ones behind the scenes controlling Deadpool. The comic ends as they deliberate over which hero to kill next.